A collection of published articles from members of the Department of Chemistry and Biochemistry.

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Submissions from 2003

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3-Indolyl-1-naphthylmethanes: New Cannabimimetic Indoles. Provide Evidence for Aromatic Stacking Interactions with the. CB1 Cannabinoid Receptor, John W. Huffman, Ross Mabon, Ming-Jung Wu, Jianzhong Lu, Richard E. Hart, Dow P. Hurst, Patricia H. Reggio, Jenny L. Wiley, and Billy R. Martin

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The Preparation, Characterization, and X-Ray Structural Analysis of Dichlorobis[1-methyl-3-(2-propyl)-2(3H)-imidazolethione]mercury(II), Anna M. Hutchings, Natalia E. McConnell, Roland A. Faucher, Donald VanDerveer, and Daniel J. Williams

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The Name Game: Learning the Connectivity between the Concepts, Marina C. Koether

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An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region, Denise McAllister, Gulrukh Rizvi, Sharon Anavi-Goffer, Dow P. Hurst, Judy Barnett-Norris, Diane L. Lynch, Patricia H. Reggio, and Mary E. Abood

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Pharmacophores for Ligand Recognition and Activation/Inactivation of the Cannabinoid Receptors, Patricia H. Reggio

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The Preparation and Structural Characterization of 1-methylimidazolium and 1,3-dimethylimidazolium Tetrachlorobismuthate(III), Daniel J. Williams, William T. Pennington, Donald VanDerveer, Jeffrey T. Anderton, and Kathleen M. White

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Teaching Environmental Chemistry with Wetland Microcosms, Daniel J. Williams, Martha C. Williams, Barbara E. Foster, Jane C. Malone, Erin E. Milner, Andrew L. Tartaglia, Angel Turner-Reed, and Marina Koether

Submissions from 2002

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Agonist Alkyl Tail Interaction with Cannabinoid CB1 Receptor V6.43/I6.46 Groove Induces a Helix 6 Active Conformatio, Judy Barnett-Norris, Dow P. Hurst, Kurt Buehner, Juan A. Ballesteros, Frank Guarnieri, and Patricia H. Reggio

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Conformational Memories and the Endocannabinoid Binding Site at the Cannabinoid CB1 Receptor, Judy Barnett-Norris, Dow P. Hurst, Diane L. Lynch, Frank Guarnieri, Alex Makriyannis, and Patricia H. Reggio

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Collaboration between Chemistry and Biology to Introduce Spectroscopy, Electrophoresis, and Molecular Biology as Tools for Biochemistry, Vicky L. H. Bevilacqua, Jennifer L. Powers, Dale L. Vogelien, Ralph J. Rascati, Michelle Hall, Kathleen Diehl, Connie Tran, Swapan S. Jain, and Reem Chabayta

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N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) Interaction with LYS 3.28(192) Is Crucial for Its Inverse Agonism at the Cannabinoid CB1 Receptor, Dow P. Hurst, Diane L. Lynch, Judy Barnett-Norris, Steven M. Hyatt, Herbert H. Seltzman, Miao Zhong, Zhao-Hui Song, Jingjiang Nie, Deborah Lewis, and Patricia H. Reggio

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The Role of Size Exclusion Chromatography-Flame Atomic Absorption Spectrometry in the Treatment Chemistry of Potable Water, Marina C. Koether

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Acid–Base Titration: Analysis of Phosphoric Acid Anodizing Solutions. A Problem-Based Learning Approach, Marina C. Koether and Charles R. Munafo

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Interdisciplinary Undergraduate Education: Environmental Studies, Marina Koether, Donald McGarey, Mark Patterson, and Daniel J. Williams

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A Critical Role for a Tyrosine Residue in the Cannabinoid Receptors for Ligand Recognition, Sean D. McAllister, Qing Tao, Judy Barnett-Norris, Kurt Buehner, Dow P. Hurst, Frank Guarnieri, Patricia H. Reggio, Katharine W. Nowell Harmon, Guy A. Cabral, and Mary E. Abood

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Endocannabinoid Structure–Activity Relationships for Interaction at the Cannabinoid Receptors, Patricia H. Reggio

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Activation of the Cannabinoid CB1 Receptor May Involve a W6.48/F3.36 Rotamer Toggle Switch, Rajnish Singh, Dow P. Hurst, Judy Barnett-Norris, Frank Guarnieri, and Patricia H. Reggio

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First-Year Undergraduate Laboratory Experiments with Zeolites, Daniel J. Williams, Benjamin E. Huck, and Angus P. Wilkinson

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1-Methyl-3-alkyl-2(3H)imidazolethione Complexes of Metal Halides: A Thematic-Ligand Approach to Involve Undergraduates in Research Projects, Daniel J. Williams, Segmia K. Tata, Marina Koether, Vicky L. H. Bevilacqua, Benjamin E. Huck, and Richard E. Hart

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Dichlorobis[1,3-dimethyl-2(3H)-imidazoleselone]zinc(II): A Potential Zinc Selenide Synthon, Daniel J. Williams, Kathleen M. White, Donald VanDerveer, and Angus P. Wilkinson

Submissions from 2001

Mass Spectrometry Forum - High-Vacuum Pumps in Mass Spectrometers, Kenneth L. Busch

Units in Mass Spectrometry, Kenneth L. Busch

Submissions from 1999

Matrices for MALDI, Kenneth L. Busch

Mechanisms of MALDI, Kenneth L. Busch

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Correlation of Second Virial Coefficients and Solubilities Useful in Protein Crystal Growth, B. Gao, S. M. Kao, H. M. McDonald, A. N. Asanov, Leon L. Combs, and W. William Wilson

Ligand-Ligand and Ligand-Receptor Approaches to Modeling the Cannabinoid CB1 and CB2 Receptors: Achievements and Challenges, Patricia H. Reggio

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The Difference between the CB1 and CB2Cannabinoid Receptors at Position 5.46 Is Crucial for the Selectivity of WIN55212-2 for CB2, Zhao-Hui Song, Carol-Anne Slowey, Dow P. Hurst, and Patricia H. Reggio

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Role of a Conserved Lysine Residue in the Peripheral Cannabinoid Receptor (CB2): Evidence for Subtype Specificity, Qing Tao, Sean D. McAllister, John Andreassi, Katherine W. Nowell, Guy A. Cabral, Dow P. Hurst, Kevin Bachtel, Marie C. Ekman, Patricia H. Reggio, and Mary E. Abood

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Main Group Metal Halide Complexes with Sterically Hindered Thioureas. XVI. The Synthesis, Characterization, and Crystal Structures of Two New Complexes Of 1,3-dimethyl-2(3H)-imidazolethione with Indium Trihalides, Daniel J. Williams, Vicky L. H. Bevilacqua, Peter A. Morson, Kelly J. Dennison, William T. Pennington, George L. Schimek, Donald VanDerveer, John S. Kruger, and Nancy T. Kawai

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Iridium(III) Amine Complexes as High-Stability Structure-Directing Agents for the Synthesis of Metal Phosphates, Daniel J. Williams, Jacob S. Kruger, A. F. McLeroy, Angus P. Wilkinson, and Jonathon C. Hanson

Submissions from 1998

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Exploration of Biologically Relevant Conformations of Anandamide, 2-Arachidonylglycerol, and Their Analogues Using Conformational Memories, Judy Barnett-Norris, Frank Guarnieri, Dow P. Hurst, and Patricia H. Reggio

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The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from (E)- and (Z)-Naphthylidene Indenes, Patricia H. Reggio, Sharmista Basu-Dutt, Judy Barnett-Norris, Marie T. Castro, Dow P. Hurst, Herbert H. Seltzman, Michael J. Roche, Anne F. Gilliam, Brian F. Thomas, L. A. Stevenson, Roger G. Pertwee, and Mary E. Abood

Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit, Stephen F. Traynelis, Michele F. Burgess, Fang Zheng, Polina Lyuboslavsky, and Jennifer L. Powers

Submissions from 1997

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Simultaneous Determination of Aspirin, Salicylamide, and Caffeine in Pain Relievers by Target Factor Analysis, Melissa J. Charles, Nea W. Martin, and Huggins Z. Msimanga

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Evidence against Cannabinoid Receptor Involvement in Intraocular Pressure Effects of Cannabinoids in Rabbits, Linda C. Hodges, Patricia H. Reggio, and Keith Green

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Importance of the C-1 Substituent in Classical Cannabinoids to CB2 Receptor Selectivity: Synthesis and Characterization of a Series of O,2-Propano-Δ8-tetrahydrocannabinol Analogs, Patricia H. Reggio, Tiansheng Wang, Amy E. Brown, Denise N. Fleming, Herbert H. Seltzman, Graeme Griffin, Roger G. Pertwee, David R. Compton, Mary E. Abood, and Billy R. Martin

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Importance of the C-1 Substituent in Classical Cannabinoids to CB2Receptor Selectivity:  Synthesis and Characterization of a Series of O,2-Propano-Δ8-tetrahydrocannabinol Analogs, Patricia H. Reggio, Tiasheng Wang, Amy E. Brown, and Denise N. Fleming

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Dichlorobis[1,3-dimethylimidazole-2(3H)-selone-Se]cobalt(II), Daniel J. Williams, Timothy Jones, Edward D. Rice, Kerri J. Davis, John A. Ritchie, William T. Pennington, and George L. Schimek

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Dichlorobis[1-methyl-3-(prop-2-enyl)imidazole-2(3H)-thione-S]zinc(II), Daniel J. Williams, Tuan A. Ly, Jeffrey W. Mudge, William T. Pennington, and George L. Schimek

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Spectroscopic Properties and Molecular Structure of 1,3-Dimethyl-2-(Se, Se-dibromoseleno)-2(3H)-imidazolylidene, Daniel J. Williams, Donald VanDerveer, Brian R. Crouse, Rhonda R. Raye, Ted Carter, Karl S. Hagen, and Meggan Brewer

Submissions from 1995

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Construction of a 3D Model of the Cannabinoid CB1 Receptor: Determination of Helix Ends and Helix Orientation, R. D. Bramblett, Al M. Panu, Juan A. Ballesteros, and Patricia H. Reggio

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Computer-Generated Ternary Phase Diagram, Leon L. Combs and Gregory W. Lynn

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Stereoselective Synthesis of the Epimeric Δ7-Tetrahydrocannabinols, John W. Huffman, W. Kenneth Banner, Grace K. Zaroob, H. Howard Joyner, Patricia H. Reggio, Billy R. Martin, and David R. Compton

Construction of a Steric Map of the Binding Pocket for Cannabinoids at the Cannabinoid Receptor, Supriya G. Lagu, Angelina Varona, James D. Chambers, and Patricia H. Reggio

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Handling Low Frequency Drifting Background Noise in Data from a Swept-Potential Electrochemical Detector, Huggins Z. Msimanga and Peter E. Sturrock

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A Review of Recent Advances in Cannabinoid Research and the 1994 International Symposium on Cannabis and the Cannabinoids, Richard E. Musty, Patricia H. Reggio, and Paul Consroe

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The Design, Synthesis and Testing of Desoxy-CBD: Further Evidence for a Region of Steric Interference at the Cannabinoid Receptor, Patricia H. Reggio, R. D. Bramblett, H. Yuknavich, Herbert H. Seltzman, Denise N. Fleming, Suresh R. Fernando, L. A. Stevenson, and Roger G. Pertwee

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Main Group Metal Halide Complexes with Sterically Hindered Thioureas XV. The Crystal and Molecular Structures of Two Unique Monomeric Bismuth(III) Thiocyanate Complexes with 1,3-Dimethyl-2(3H)-imidazolethione, Daniel J. Williams, Ted Carter, Kimberly L. Fahn, and Donald VanDerveer

Submissions from 1993

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Molecular Determinants of Cannabinoid Activity: Toward the Design of Cannabinoid Analgesics with Reduced Psychoactive Liability, Patricia H. Reggio

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Characterization of a Region of Steric Interference at the Cannabinoid Receptor Using the Active Analog Approach, Patricia H. Reggio, Al M. Panu, and Scott Miles

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Synthesis, Characterization, and X-Ray Crystallographic Structure of 1,3-dimethyl-2(3H)-imidazoleselone, Daniel J. Williams, Melissa R. Fawcett-Brown, Rhonda R. Raye, Donald VanDerveer, Yong T. Pang, Robert L. Jones, and Katrina L. Bergbauer

Submissions from 1991

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Extract of tobacco Callus with Antiglaucoma Activity, Linda C. Hodges, George W. Robinson, and Keith Green

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A Rational Search for the Separation of Psychoactivity and Analgesia in Cannabinoids, Patricia H. Reggio, G. B. McGaughey, Denise F. Odear, Herbert H. Seltzman, David R. Compton, and Billy R. Martin

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Synthesis of Rotationally Restricted Tetrahydrocannabinol Ethers, Herbert H. Seltzman, Yung Ho Hsieh, Colin G. Pitt, and Patricia H. Reggio

Submissions from 1990

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Application of Factor Analysis on High-Performance Liquid Chromatography Data Using a Swept-Potential Electrochemical Detection System, Huggins Z. Msimanga and Peter E. Sturrock

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A Molecular Reactivity Template for Cannabinoid Analgesic Activity, Patricia H. Reggio, Vladimir Frecer, and Aleksander P. Mazurek

Submissions from 1987

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Synthesis and Characterization of Tris[P,P,P',P'-Tetramethylimidobis (Phosphine Sulfido)S,S'] Bismuth(III), Daniel J. Williams, Johnnie B. Travis, and Katrina L. Bergbauer

Submissions from 1986

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Synthesis, Properties, and Structure of 1,3-dimethyl-2(3H)-imidazolethione Hydrogen Bromide, Daniel J. Williams, Guillermo Ramirez, and Donald VanDerveer

Submissions from 1985

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Polysaccharides from Cannabis Sativa Active in Lowering Intraocular Pressure, Linda Hodges, Howard M. Deutsch, Keith Green, and Leon H. Zalkow

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A Modified Procedure for the Preparation of 5H,7H-Dibenzo[C,E]Selenepin, Daniel J. Williams, Patrick K. Macy, and David R. Hezs

Submissions from 1984

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Marihuana-Derived Material: Distribution and Effects after Systemic Administration, Keith Green, Kenneth Cheeks, Karen A. Bowman, Linda C. Hodges, Howard M. Deutsch, and Leon H. Zalkow

Submissions from 1982

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Crystal and Molecular Structure of Tris[P,P,P',P'-tetraphenylamidobis(phosphine sulfido)-S,S')bismuth(III), Daniel J. Williams, Carl O. Quicksall, and Kathleen M. Barkigia

Di-μ-chlorobis[1,3-dimethyl-2(3H)-imidazolethione]dichlorobismuth(III), C20H32Bi2Cl6N8S4, Daniel J. Williams, Byron Rubin, Jay Epstein, Walter K. Dean, and Alfred Viehbeck

Submissions from 1981

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Crystal and molecular structure of trichloro[1,3-dimethyl-2(3H)-imidazolethione]antimony(III), Byron Rubin, F. J. Heldrich, Walter K. Dean, Daniel J. Williams, and Alfred Viehbeck

Submissions from 1980

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Complexes of Bi(III) with Tetraphenylimidodiphosphinate Ligands, Daniel J. Williams