Entrepreneurship education is a catalyst for the diminution of unemployment in Sierra Leone. The study evaluates the causal nexus between entrepreneurship education and self-employment initiatives among Fourah Bay College students. Using regression analysis, data collected were primary data through the administration of questionnaires and simple percentage ranking techniques were used to analyze the questionnaires. The result shows that entrepreneurship education is an important policy and it has positive effect on self-employment initiatives. From the study, the following are some of the recommendations: The University of Sierra Leone should establish a center for entrepreneurship and innovation that will offer degree programs in entrepreneurship education. Entrepreneurship education facilitators should be people who are not only qualify academically but have the practical experience as well. Business competitions should be held for students. This will accelerate the self-employment initiatives among students.