Disciplines
Dietetics and Clinical Nutrition
Abstract (300 words maximum)
Currently, there is limited research investigating the effects of quercetin on bone turnover and density. Therefore, this study aimed to examine the efficacy of 90-day quercetin supplementation on bone turnover, inflammation, body composition, and physical function in postmenopausal women. Thirty-four healthy postmenopausal women (59.2 ± 7.0 yrs, 80.7 ± 15.6 kg, 29.8 ± 6.1 kg⸱m2) participated in the double-blind placebo-controlled investigation. Participants were randomly assigned to one of two groups: 500 mg of Q or 500 mg of fiber (placebo; PLB). Data collected during the pre-and post-supplementation assessments included: bone turnover (osteocalcin, P1NP, CTX), inflammation markers (IL-6, TNF-alpha, CRP), body composition, dominant handgrip strength, and timed up and go test. Independent samples t-tests were used for between-group comparisons of baseline values and the percent change for each dependent variable. A significant difference in percent change for osteocalcin (Q: 20.5±25.7; PLB: 1.3±17.2; p=0.016; d=0.89), P1NP (Q: 28.9 (6.0–57.3); PLB: 4.6 (-7.6 – 8.5); p=0.030; d=0.64), and CTX (Q: 39.0 (-10.0 – 84.6); PLB: -7.74 (-28.9 – 18.5); p=0.023; d=0.91) was found between Q and PLB, with greater increases in Q. Changes in the inflammation markers IL-6 (Q: -17.6±24.1; PLB: 2.90±31.1; p=0.045; d=0.73) and TNF-alpha (Q: -4.9± (-15.3 – [-3.2]); PLB: 1.9 (-7.8 – 4.0); p=0.021; d=0.90) between the two groups were significant. No significant changes were found between groups for CRP, body composition, and physical function (p>0.05). The data suggest that Q may improve bone health status in postmenopausal women through its ability to decrease pro-inflammatory mediators and increase turnover markers.
Academic department under which the project should be listed
WCHHS - Exercise Science and Sport Management
Primary Investigator (PI) Name
Trisha A. VanDusseldorp
Additional Faculty
Garrett M. Hester, ghester4@kennesaw.edu
Included in
The effect of chronic quercetin supplementation on bone health in postmenopausal women: A double-blind placebo-controlled investigation
Currently, there is limited research investigating the effects of quercetin on bone turnover and density. Therefore, this study aimed to examine the efficacy of 90-day quercetin supplementation on bone turnover, inflammation, body composition, and physical function in postmenopausal women. Thirty-four healthy postmenopausal women (59.2 ± 7.0 yrs, 80.7 ± 15.6 kg, 29.8 ± 6.1 kg⸱m2) participated in the double-blind placebo-controlled investigation. Participants were randomly assigned to one of two groups: 500 mg of Q or 500 mg of fiber (placebo; PLB). Data collected during the pre-and post-supplementation assessments included: bone turnover (osteocalcin, P1NP, CTX), inflammation markers (IL-6, TNF-alpha, CRP), body composition, dominant handgrip strength, and timed up and go test. Independent samples t-tests were used for between-group comparisons of baseline values and the percent change for each dependent variable. A significant difference in percent change for osteocalcin (Q: 20.5±25.7; PLB: 1.3±17.2; p=0.016; d=0.89), P1NP (Q: 28.9 (6.0–57.3); PLB: 4.6 (-7.6 – 8.5); p=0.030; d=0.64), and CTX (Q: 39.0 (-10.0 – 84.6); PLB: -7.74 (-28.9 – 18.5); p=0.023; d=0.91) was found between Q and PLB, with greater increases in Q. Changes in the inflammation markers IL-6 (Q: -17.6±24.1; PLB: 2.90±31.1; p=0.045; d=0.73) and TNF-alpha (Q: -4.9± (-15.3 – [-3.2]); PLB: 1.9 (-7.8 – 4.0); p=0.021; d=0.90) between the two groups were significant. No significant changes were found between groups for CRP, body composition, and physical function (p>0.05). The data suggest that Q may improve bone health status in postmenopausal women through its ability to decrease pro-inflammatory mediators and increase turnover markers.