Crystallizations of Nanoceria Extracted From a Soluble Borate Glass
Primary Investigator (PI) Name
Kisa Ranasinghe
Department
CSM - Physics
Abstract
Research in bioactive glass has not yet reached its full potential because there is little data on emerging applications. We are currently investigating a glass that can be used as both a carrier and a creator of therapeutic nanoceria. We have obtained proof that cerium can exist in both trivalent Ce3+ (Ce2O3 -reduced) and tetravalent Ce4+ (CeO2-oxidized) states within the glass, with varying Ce3+/Ce4+ ratios, using X-Ray Absorption Near Edge Structure (XANES) spectroscopy. This coexistence of Ce4+ and Ce3+ ions facilitate redox reactions which mimic the action of two key antioxidant enzymes, providing numerous health benefits. In this study, a soluble borate glass composition was doped with various amounts of cerium oxide and processed with various melting parameters to create cerium oxide nanoparticles with varying ratios of Ce3+/Ce4+embedded within the glass. These glass samples were then crushed down to obtain < 30µm size of glass powder, the soluble glass powders dissolved in DI water, and then centrifuged to extract the nanoparticles. Thermal characteristics of the extracted nanoceria were studied with un-doped borate glass as well as cerium doped glass powder using Differential Thermal Analysis (DTA). Doped and un-doped samples exhibited similar glass transitions. Doped glass samples and extracted nanoceria exhibited similar exothermic peaks that are not presented in un-doped samples, which indicate a possible crystallization of nanoceria.
Disciplines
Other Physics
Crystallizations of Nanoceria Extracted From a Soluble Borate Glass
Research in bioactive glass has not yet reached its full potential because there is little data on emerging applications. We are currently investigating a glass that can be used as both a carrier and a creator of therapeutic nanoceria. We have obtained proof that cerium can exist in both trivalent Ce3+ (Ce2O3 -reduced) and tetravalent Ce4+ (CeO2-oxidized) states within the glass, with varying Ce3+/Ce4+ ratios, using X-Ray Absorption Near Edge Structure (XANES) spectroscopy. This coexistence of Ce4+ and Ce3+ ions facilitate redox reactions which mimic the action of two key antioxidant enzymes, providing numerous health benefits. In this study, a soluble borate glass composition was doped with various amounts of cerium oxide and processed with various melting parameters to create cerium oxide nanoparticles with varying ratios of Ce3+/Ce4+embedded within the glass. These glass samples were then crushed down to obtain < 30µm size of glass powder, the soluble glass powders dissolved in DI water, and then centrifuged to extract the nanoparticles. Thermal characteristics of the extracted nanoceria were studied with un-doped borate glass as well as cerium doped glass powder using Differential Thermal Analysis (DTA). Doped and un-doped samples exhibited similar glass transitions. Doped glass samples and extracted nanoceria exhibited similar exothermic peaks that are not presented in un-doped samples, which indicate a possible crystallization of nanoceria.