Project Title

Role of Ce EFN-4 in gustatory sensory ASE neuron

Presenters

Barrett UptonFollow

Academic department under which the project should be listed

CSM - Molecular and Cellular Biology

Faculty Sponsor Name

Martin Hudson

Additional Faculty

Karuna Kalichamy, Molecular and Cellular Biology, kkalicha@kennesaw.edu

Does not need to because we work on worms.

Abstract (300 words maximum)

During nervous system development, axons rely on guidance when growing. The molecules that help them grow are called guidance molecules and there is a specific family of them called ephrins. These membrane-associated ephrins work together with the cognate Eph receptors to help guide the axon development. Here, we are interested in studying the role of C. elegans efn-4 in axon guidance and the development of gustatory sensory neurons ASE. We crossed the transgenes of otIs3(gcy-7::GFP) and ntIs1(gcy-5p::GFP) into an efn-4 deficient mutant by following conventional breeding methods and imaging. Currently, Hudson and co-workers are investigating the pivotal role of the Eph receptors and ephrin ligands in gustatory neurons and chemotaxis.

Project Type

Event

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Role of Ce EFN-4 in gustatory sensory ASE neuron

During nervous system development, axons rely on guidance when growing. The molecules that help them grow are called guidance molecules and there is a specific family of them called ephrins. These membrane-associated ephrins work together with the cognate Eph receptors to help guide the axon development. Here, we are interested in studying the role of C. elegans efn-4 in axon guidance and the development of gustatory sensory neurons ASE. We crossed the transgenes of otIs3(gcy-7::GFP) and ntIs1(gcy-5p::GFP) into an efn-4 deficient mutant by following conventional breeding methods and imaging. Currently, Hudson and co-workers are investigating the pivotal role of the Eph receptors and ephrin ligands in gustatory neurons and chemotaxis.