Project Title
Role of Ce EFN-4 in gustatory sensory ASE neuron
Disciplines
Developmental Neuroscience
Abstract (300 words maximum)
During nervous system development, axons rely on guidance when growing. The molecules that help them grow are called guidance molecules and there is a specific family of them called ephrins. These membrane-associated ephrins work together with the cognate Eph receptors to help guide the axon development. Here, we are interested in studying the role of C. elegans efn-4 in axon guidance and the development of gustatory sensory neurons ASE. We crossed the transgenes of otIs3(gcy-7::GFP) and ntIs1(gcy-5p::GFP) into an efn-4 deficient mutant by following conventional breeding methods and imaging. Currently, Hudson and co-workers are investigating the pivotal role of the Eph receptors and ephrin ligands in gustatory neurons and chemotaxis.
Academic department under which the project should be listed
CSM - Molecular and Cellular Biology
Primary Investigator (PI) Name
Martin Hudson
Additional Faculty
Karuna Kalichamy, Molecular and Cellular Biology, kkalicha@kennesaw.edu
Role of Ce EFN-4 in gustatory sensory ASE neuron
During nervous system development, axons rely on guidance when growing. The molecules that help them grow are called guidance molecules and there is a specific family of them called ephrins. These membrane-associated ephrins work together with the cognate Eph receptors to help guide the axon development. Here, we are interested in studying the role of C. elegans efn-4 in axon guidance and the development of gustatory sensory neurons ASE. We crossed the transgenes of otIs3(gcy-7::GFP) and ntIs1(gcy-5p::GFP) into an efn-4 deficient mutant by following conventional breeding methods and imaging. Currently, Hudson and co-workers are investigating the pivotal role of the Eph receptors and ephrin ligands in gustatory neurons and chemotaxis.