Role of Ce EFN-4 in gustatory sensory ASE neuron
Primary Investigator (PI) Name
Martin Hudson
Department
CSM - Molecular and Cellular Biology
Abstract
During nervous system development, axons rely on guidance when growing. The molecules that help them grow are called guidance molecules and there is a specific family of them called ephrins. These membrane-associated ephrins work together with the cognate Eph receptors to help guide the axon development. Here, we are interested in studying the role of C. elegans efn-4 in axon guidance and the development of gustatory sensory neurons ASE. We crossed the transgenes of otIs3(gcy-7::GFP) and ntIs1(gcy-5p::GFP) into an efn-4 deficient mutant by following conventional breeding methods and imaging. Currently, Hudson and co-workers are investigating the pivotal role of the Eph receptors and ephrin ligands in gustatory neurons and chemotaxis.
Disciplines
Developmental Neuroscience
Role of Ce EFN-4 in gustatory sensory ASE neuron
During nervous system development, axons rely on guidance when growing. The molecules that help them grow are called guidance molecules and there is a specific family of them called ephrins. These membrane-associated ephrins work together with the cognate Eph receptors to help guide the axon development. Here, we are interested in studying the role of C. elegans efn-4 in axon guidance and the development of gustatory sensory neurons ASE. We crossed the transgenes of otIs3(gcy-7::GFP) and ntIs1(gcy-5p::GFP) into an efn-4 deficient mutant by following conventional breeding methods and imaging. Currently, Hudson and co-workers are investigating the pivotal role of the Eph receptors and ephrin ligands in gustatory neurons and chemotaxis.