Project Title

The role of Biofilm formation in Candida auris Anti-fungal Susceptibility

Presenters

kameron downsFollow

Academic department under which the project should be listed

CSM - Molecular and Cellular Biology

Faculty Sponsor Name

Christopher Cornelison

no human subjects

Abstract (300 words maximum)

Candida auris is an emerging fungal pathogen that presents as a serious health threat that commonly causes nosocomial blood infections in the immunocompromised. Three distinct factors make this pathogen a global threat. First, it is drug-resistance, some isolates are resistant to more than one class of anti-fungal. Secondly, it causes nosocomial outbreaks and lives on finite for weeks. Third, it is commonly misidentified by diagnostic platforms. Recent research has found that like in other Candida species, biofilm formation maybe a key virulence factor for C. auris. In this study, we compared anti-fungal susceptibility of several C. auris isolates and other related Candida species. Various antifungals were tested against platonic and adhered cells using crystal violet assay. The goal of this study is to see the importance of biofilm formation in C. auris antifungal susceptibility.

Project Type

Event

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The role of Biofilm formation in Candida auris Anti-fungal Susceptibility

Candida auris is an emerging fungal pathogen that presents as a serious health threat that commonly causes nosocomial blood infections in the immunocompromised. Three distinct factors make this pathogen a global threat. First, it is drug-resistance, some isolates are resistant to more than one class of anti-fungal. Secondly, it causes nosocomial outbreaks and lives on finite for weeks. Third, it is commonly misidentified by diagnostic platforms. Recent research has found that like in other Candida species, biofilm formation maybe a key virulence factor for C. auris. In this study, we compared anti-fungal susceptibility of several C. auris isolates and other related Candida species. Various antifungals were tested against platonic and adhered cells using crystal violet assay. The goal of this study is to see the importance of biofilm formation in C. auris antifungal susceptibility.