Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy

Authors

Kyle R. Cowdrick, Emory University
Mariam Akbar, Emory University
Tisha Boodooram, Emory University
Labeausha H. Harris, Emory University
Shasha Bai, Emory University School of Medicine
Rowan O. Brothers, Emory University
Michael Arrington, Emory University
Seung Yup Lee, Kennesaw State University
Kirsma Khemani, AFLAC Incorporated
Beatrice Gee, AFLAC Incorporated
Erin M. Buckley, Emory University

Department

Electrical and Computer Engineering

Document Type

Article

Publication Date

1-1-2023

Abstract

Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response to a vasodilatory stimulus, is an integral mechanism in brain homeostasis that is thought to be impaired in sickle cell disease (SCD). This study used diffuse correlation spectroscopy and a simple breath-hold stimulus to quantify CVR non-invasively in a cohort of 12 children with SCD and 14 controls. Median [interquartile range] CVR was significantly decreased in SCD compared to controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide a feasible means to routinely monitor CVR impairments in pediatric SCD.

Journal Title

Biomedical Optics Express

Journal ISSN

2156-7085

Volume

14

Issue

11

First Page

5696

Last Page

5708

Digital Object Identifier (DOI)

10.1364/BOE.499274