Maini's many contributions to mathematical enzyme kinetics: A review
Department
Mathematics
Document Type
Article
Publication Date
12-14-2018
Abstract
Modelling enzyme kinetics has a long history, as one of the earliest areas where mathematics was utilized to understand biological (in this case, biochemical) phenomena. By using differential equations and the law of mass action, many researchers have discovered information about the mechanisms of enzyme workings in the more than 100 years since Leonor Michaelis and Maud Menten published their classic paper in 1913. This work uses he laws obeyed by molecules during a reaction, translates them into mathematical equations, and then compares the results predicted by the equations to data obtained in laboratory conditions. This can inform whether the mechanism used to create the mathematical model is consistent with experimental results. Philip K. Maini has contributed to several significant results in the field of mathematical modelling in enzyme kinetics. Along with his collaborators, he has published results analyzing and extending the Quasi-Steady State Assumption, applying it to special enzyme reactions, and considering special conditions. This review paper will provide an overview of the contributions made by PK Maini to the field of modelling enzyme kinetics, summarize the main results and discuss their significance.
Journal Title
Journal of Theoretical Biology
Journal ISSN
0022-5193
Digital Object Identifier (DOI)
10.1016/j.jtbi.2018.12.003