Location
https://www.kennesaw.edu/ccse/events/computing-showcase/sp26-cday-program.php
Document Type
Event
Start Date
22-4-2026 4:00 PM
Description
We study whether topological loss-based constraints improve multidomain whole-chain protein structure prediction beyond the ColabFold baseline by better preserving the topologies of folded proteins. We benchmark against Wasserstein metrics with our own virtual persistence and RKHS semi-metric constraints as well as higher-order virtual persistence diagrams.
Included in
GRP-02-199 Topological Constraints for Protein Folding
https://www.kennesaw.edu/ccse/events/computing-showcase/sp26-cday-program.php
We study whether topological loss-based constraints improve multidomain whole-chain protein structure prediction beyond the ColabFold baseline by better preserving the topologies of folded proteins. We benchmark against Wasserstein metrics with our own virtual persistence and RKHS semi-metric constraints as well as higher-order virtual persistence diagrams.