Location
https://www.kennesaw.edu/ccse/events/computing-showcase/sp26-cday-program.php
Document Type
Event
Start Date
22-4-2026 4:00 PM
Description
Parametric approaches, such as Mixed Models for Repeated Measures (MMRM), are standard in Alzheimer’s Disease (AD) clinical trials. However, these models often falter when data violates assumptions of normality or follows non-linear trajectories—common occurrences in AD due to floor/ceiling effects on cognitive scales and heterogeneous disease progression. This study evaluates Longitudinal Rank Sum Tests (LRST) as a non-parametric alternative to maintain statistical power and robustness.
Included in
GRM-081-207 Leveraging Non-Parametric Longitudinal Rank Sum Tests (LRST) for Robust Global Treatment Effect Estimation in Alzheimer’s Disease
https://www.kennesaw.edu/ccse/events/computing-showcase/sp26-cday-program.php
Parametric approaches, such as Mixed Models for Repeated Measures (MMRM), are standard in Alzheimer’s Disease (AD) clinical trials. However, these models often falter when data violates assumptions of normality or follows non-linear trajectories—common occurrences in AD due to floor/ceiling effects on cognitive scales and heterogeneous disease progression. This study evaluates Longitudinal Rank Sum Tests (LRST) as a non-parametric alternative to maintain statistical power and robustness.