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The early post-independence periods saw Africa have efficient Public Sector Institutions. Over a decade, there seems to be a decadent in the public sector. The study examines the regional analysis of government effectiveness in Africa. The study uses data given by the World Bank's Governance Indicator from 55 African countries from 2002 to 2018. The study uses Panel Regression Analysis Model of Random Effects and Pooled Ordinary Least Squares to assess government effectiveness in the five regions of Africa. The findings indicate that Southern African countries performed best as compared to its counterpart regions, followed by North Africa. However, East, West and Central African countries had low scores on government effectiveness. The results imply that electoral politics and political interference hurt the performances of public institutions on the continent.