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Aggressive tax practices are significantly detrimental to developing countries in Africa not just to their economies or the strengths of their legal frameworks, but also to the organizational structures needed for the operation of society and good quality of life in these countries. However, it is possible to reduce and reverse the detrimental effects of aggressive tax practices by employing an effective regime that tackles the issue. This article evaluates whether the Organization for Economic Cooperation and Development (OECD), successfully combats aggressive tax practices carried out by multinational enterprises (MNEs) and how the African Union may learn from the OECD's efforts when forming its own regime for combatting such practices. Since the OECD lacks African representation in its core membership, the aim of this article is to offer the African Union an appropriate and Afrocentric solution to the econo-socio-legal problems that aggressive tax practices pose in the continent.