Domestic Resource Mobilization (DRM) is "the generation of government revenue from domestic resources, from tax and non-tax sources (royalties, licenses, levies or other income)" (European Commission, 2010). Major scholars have exchanged contrasting views on the barriers to resource mobilization in Africa. While Di John (2006) asserts weak state capacity to mobilizing resources and the need for reconstruction of a viable state, Von (2007) contends that neopatrimonialism has inhibited African state's revenue. Furthermore, Elbadawi (2000) maintains that low savings and investments are the impediments of resource generation and the declining performance of Africa. This paper therefore argues that the weak state capacity of African countries is the key constraint facing African countries in mobilizing their resources for development using Ghana and Zambia as case studies. The next sections of the paper are organized as follows: first the paper will accentuate on the weak state capacity, secondly it will argue how weak state capacity has led to key constraints in mobilizing resources. Finally the paper will make conclusions and recommendations.