SWIR SCOS for Deep Tissue Flowmeter
Disciplines
Bioimaging and Biomedical Optics
Abstract (300 words maximum)
Multiple optical techniques have been explored to non-invasively assess tissue blood flow using the principle of dynamic light scattering. Speckle contrast optical spectroscopy (SCOS) has been developed to exploit the advantages of Laser Speckle Contrast Imaging (LSCI) and Diffuse Correlation Spectroscopy (DCS) and offer more than an order of magnitude improvement in signal-to-noise ratio (SNR) with a lower price for cerebral blood flow (CBF) monitoring. Unlike DCS using a temporal dynamic of speckles, SCOS measures spatial speckle contrasts from the multiple camera pixels that detect photons undergone multiple scattering. However, at source–detector separations (SDS) >2 cm, the SNR remains limiting for adult cerebral measurements lacking accurate quantification of cerebral blood flow. In this study, we aim to explore operating SCOS through the shortwave infrared (SWIR, 900-1700nm) range, particularly, 1064nm which can improve depth sensitivity and SNR due to the known advantages of reduced tissue scattering while retaining adequate tissue transmission and we will compare NIRs SCOS in 852nm using long-coherence length laser (iBeam Smart, Toptica 852nm, 150mW, > 50m, ) versus 1064 nm and a SWIR camera (Balser a2A 1280 125um SWIR).Then, we will perform quantitative in-vitro studies through a two-layer microfluidic phantom. This study will provide the technical feasibility of SCOS at 1064 nm to offer a unique opportunity for deeper tissue flow sensing than the NIR region.
Use of AI Disclaimer
no
Academic department under which the project should be listed
SPCEET – Electrical and Computer Engineering
Primary Investigator (PI) Name
Paul Lee
SWIR SCOS for Deep Tissue Flowmeter
Multiple optical techniques have been explored to non-invasively assess tissue blood flow using the principle of dynamic light scattering. Speckle contrast optical spectroscopy (SCOS) has been developed to exploit the advantages of Laser Speckle Contrast Imaging (LSCI) and Diffuse Correlation Spectroscopy (DCS) and offer more than an order of magnitude improvement in signal-to-noise ratio (SNR) with a lower price for cerebral blood flow (CBF) monitoring. Unlike DCS using a temporal dynamic of speckles, SCOS measures spatial speckle contrasts from the multiple camera pixels that detect photons undergone multiple scattering. However, at source–detector separations (SDS) >2 cm, the SNR remains limiting for adult cerebral measurements lacking accurate quantification of cerebral blood flow. In this study, we aim to explore operating SCOS through the shortwave infrared (SWIR, 900-1700nm) range, particularly, 1064nm which can improve depth sensitivity and SNR due to the known advantages of reduced tissue scattering while retaining adequate tissue transmission and we will compare NIRs SCOS in 852nm using long-coherence length laser (iBeam Smart, Toptica 852nm, 150mW, > 50m, ) versus 1064 nm and a SWIR camera (Balser a2A 1280 125um SWIR).Then, we will perform quantitative in-vitro studies through a two-layer microfluidic phantom. This study will provide the technical feasibility of SCOS at 1064 nm to offer a unique opportunity for deeper tissue flow sensing than the NIR region.