Monte Carlo Damage Simulation of DNA Damage based on Feasibility of High Density I-125 Production to Enable 10 Gy/min High Dose Rate for Improved Relative Biological Effectiveness
Disciplines
Biomedical Devices and Instrumentation | Biomedical Engineering and Bioengineering | Biotechnology | Cancer Biology | Electrical and Electronics | Electromagnetics and Photonics | Molecular Biology | Nuclear Engineering | Oncology | Other Analytical, Diagnostic and Therapeutic Techniques and Equipment | Radiation Medicine | Radiology
Abstract (300 words maximum)
In our previous work, we used TOPAS Monte Carlo nuclear radiation simulations to show thefeasibility of a new type of controlled radiation capsule to enable a high dose rate of 10 Gy/min with low energy Iodine-125 sources. It has been shown that lower energy is more effective in DNA double strand breaks, and a higher dose rate of this low energy radiation has a greater relative biological effectiveness (RBE) due to the sustained double strand damage with fewer recombination.
In this work, we delve further into the actual DNA damage including single strand and double strand breaks based on different combinations of radiation energy levels and dose rates. This analysis is conducted using Monte Carlo Damage Simulation (MCDS) software.
The second part of this work is the feasibility of producing the required amount of I-125 and handling of it, in order to transfer the I-125 into our proposed capsule. This work shows the calculation of the nuclear reactor time required to convert Xe-124 to Xe-125 and then to I-125.
The third part of this work is the optimization of the electromagnet inside the capsule to control the opening and closing of the radiation capsule to release or block the radiation from outside the body. For this optimization, COMSOL Multiphysics software was used to optimize the number of turns, magnetic core, dimensions and properties of the permanent magnet. The inductive coupling from outside the body to the electromagnet inside the body was then calculated based on the current needed, which was obtained from the COMSOL simulations.
The results of this work show the feasibility of producing a very high density of I-125 for implantable brachytherapy for the first time. MCDS simulations show that this amount of I-125 indeed improves the RBE compared to conventional LDR and HDR brachytherapy methods.
Academic department under which the project should be listed
SPCEET - Electrical and Computer Engineering
Primary Investigator (PI) Name
Hoseon Lee
Monte Carlo Damage Simulation of DNA Damage based on Feasibility of High Density I-125 Production to Enable 10 Gy/min High Dose Rate for Improved Relative Biological Effectiveness
In our previous work, we used TOPAS Monte Carlo nuclear radiation simulations to show thefeasibility of a new type of controlled radiation capsule to enable a high dose rate of 10 Gy/min with low energy Iodine-125 sources. It has been shown that lower energy is more effective in DNA double strand breaks, and a higher dose rate of this low energy radiation has a greater relative biological effectiveness (RBE) due to the sustained double strand damage with fewer recombination.
In this work, we delve further into the actual DNA damage including single strand and double strand breaks based on different combinations of radiation energy levels and dose rates. This analysis is conducted using Monte Carlo Damage Simulation (MCDS) software.
The second part of this work is the feasibility of producing the required amount of I-125 and handling of it, in order to transfer the I-125 into our proposed capsule. This work shows the calculation of the nuclear reactor time required to convert Xe-124 to Xe-125 and then to I-125.
The third part of this work is the optimization of the electromagnet inside the capsule to control the opening and closing of the radiation capsule to release or block the radiation from outside the body. For this optimization, COMSOL Multiphysics software was used to optimize the number of turns, magnetic core, dimensions and properties of the permanent magnet. The inductive coupling from outside the body to the electromagnet inside the body was then calculated based on the current needed, which was obtained from the COMSOL simulations.
The results of this work show the feasibility of producing a very high density of I-125 for implantable brachytherapy for the first time. MCDS simulations show that this amount of I-125 indeed improves the RBE compared to conventional LDR and HDR brachytherapy methods.