Date of Completion

Spring 12-5-2020

Project Type

Research Project

Degree Name

Master of Science in Nursing - Educational Leadership



Committee Chair/First Advisor

Dr. Anne White


In patients with ESRD, clinicians are tentative to initiate fluid resuscitation given the chance of negative outcomes associated with fluid overload. Given this, many ESRD patients with sepsis are severely under-resuscitated with fluids and experience a delay in receiving antibiotics (Abou Dagher et al. 2015). There is also controversy surrounding the type of fluid that should be used with patients with ESRD. The mainstay fluid for treatment is 0.9% sodium chloride solution (normal saline). Patient studies have found that this fluid could be harmful to the kidneys and should not be administered in patients with kidney disease (Rochwerg et al. 2015). This tentative treatment leads to decreased patient outcomes and slows the healing process. FLUID RESUSCITATION 4

The aim of this literature review is to synthesize the studies that explored fluid resuscitation in the management of ESRD patients diagnosed with sepsis. There are retrospective as well as quasi-experimental studies available for review on the treatment of sepsis and the treatment of ESRD patients diagnosed with sepsis. These articles will be analyzed, and a synthesis of research will be developed that focuses on best practice in treating ESRD patients diagnosed with sepsis or septic shock. This integrative review will help to understand the current literature on the problem and enable future research to be performed to improve overall knowledge and practice.