This paper discusses the rapid growth of the Pearl River Delta in the southern province of Guangdong in China, not only as part of a national development strategy but also in terms of the creation of a super zone with the neighbouring areas, particularly Hong Kong. This paper shows the success of the development of the coastal region of Guangdong province and the creation of a megalopolis between the cities of Shenzhen and Hong Kong. This success is explained by the synergy created between these two neighbouring areas, particularly after Hong Kong’s reunification with China in 1997 and the Closer Economic Partnership Agreement between Hong Kong and China in 2003.