Leading universities around the globe have begun to internationalize their campuses. This effort is being driven by historic political and economic changes, changes in the academic and nonacademic environment, and by the strategic imperative for universities to remain at the forefront of its teaching, research and service missions. Universities are being asked to help meet major international challenges, to educate students in their disciplines with a sense of global competence and engagement, and to contribute to local and national economic competiveness. Faculty members must not only remain current in their disciplines globally but must also be aware of developments in key related disciplines since the nature of knowledge and the problems facing humanity are cross-disciplinary and global. How can leaders understand and manage these demands?