Unlocking the Potential of Estradiol in Posttraumatic Stress Disorder Symptom Reduction: Is Habituation the Key?
The risk for developing a trauma-related psychopathology such as posttraumatic stress disorder (PTSD) is multidetermined but depends in part on biological sex. Women develop PTSD at approximately twice the rate of men while also experiencing greater symptom severity and longer symptom duration (1). However, the mechanisms underlying women’s disproportionate PTSD risk remain grossly understudied. Because these sex disparities cannot be fully accounted for by environmental factors, such as degree of exposure to particular types of trauma, more research is needed to understand biological factors that contribute to differential PTSD risk between sexes. Importantly, we need a better understanding of dysregulated neurocircuitries in traumatized women with and without PTSD to guide better treatments that target sex-specific neurobiological features of the disorder.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Digital Object Identifier (DOI)