A Mindfulness-based Intervention for Self-Management of Verbal and Physical Aggression by Adolescents with Prader-Willi Syndrome

Document Type


Publication Date



PURPOSE: There is a dearth of clinical and research literature on the treatment of maladaptive behaviors in adolescents with Prader-Willi syndrome (PWS). The purpose of this study was to evaluate the effectiveness of a mindfulness-based intervention, Meditation on the Soles of the Feet (SoF), to facilitate self-management of verbal and physical aggression. METHOD: We utilized a multiple-baseline design across participants to test the intervention with three adolescents diagnosed with PWS. RESULTS: Relative to baseline, verbal aggression decreased to minimal levels following mindfulness-based practice and physical aggression was nearly eliminated. Intervention effects were maintained at 12-month follow-up. Quantitative analytics confirmed statistically significant outcomes. CONCLUSIONS: The SoF mindfulness intervention was effective in reducing verbal and physical aggression in three adolescents with PWS. Future research should test the SoF intervention with this clinical population in a larger clinical trial, and the SoF intervention may be applicable to other pediatric populations.

Journal Title

Developmental Neurorehabilitation

Journal ISSN


Digital Object Identifier (DOI)