Monocyte Recruitment following High-Intensity and High-Volume Resistance Exercise

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The innate immune response is generally considered to have an important role in tissue remodeling following resistance exercise. Purpose: The purpose of this study was to compare changes in markers of monocyte recruitment following an acute bout of high-intensity (HVY), versus high-volume (VOL) lower-body resistance exercise. Methods: Ten resistance-trained men (24.7±3.4y; 90.1±11.3kg; 176.0±4.9cm) performed each protocol in a randomized, counterbalanced order. Blood samples were obtained at baseline, immediately (IP), 30-minutes (30P), 1-hour (1H), 2-hours (2H), and 5-hours (5H) post-exercise. Plasma concentrations of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNFα), myoglobin and cortisol were measured via assay. Tumor necrosis factor receptor-1 (TNFr1), macrophage-1 antigen (CD11b), and C-C chemokine receptor-2 (CCR2) expressions were measured using flow cytometry. TNFr1 and CD11b were assessed on CD14++CD16- monocytes, while CCR2 was assessed on CD14+ monocytes. Results: Plasma myoglobin concentrations were significantly greater following HVY compared to VOL (p

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Medicine & Science in Sports & Exercise

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