Department
Molecular and Cellular Biology
Document Type
Article
Publication Date
1-18-2016
Abstract
MicroRNAs (miRNAs) are short sequences of noncoding single-stranded RNAs that exhibit inhibitory effects on complementary target mRNAs. Recently, it has been discovered that certain viruses express their own miRNAs, while other viruses activate the transcription of cellular miRNAs for their own benefit. This review summarizes the viral and/or cellular miRNAs that are transcribed during infection, with a focus on the biomarker and therapeutic potential of miRNAs (or their antagomirs). Several human viruses of clinical importance are discussed, namely, herpesviruses, polyomaviruses, hepatitis B virus, hepatitis C virus, human papillomavirus, and human immunodeficiency virus.
Journal Title
Biomarker Insights
Journal ISSN
1177-2719
Issue
4
First Page
25
Last Page
52
Digital Object Identifier (DOI)
10.4137/BMI.S29512