Undergraduate Analytical Chemistry: Method Development and Results of the Analysis of Bismuth in Pharmaceuticals


Chemistry & Biochemistry

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Three different methods were developed and employed to analyze the concentration of bismuth subsalicylate in an oral liquid pharmaceutical suspension. These methods were UV-Visible spectroscopy utilizing the external calibration method and the standard addition method, flame atomic absorption spectroscopy, and complexometric titration with EDTA. All three methods were conducted within one 3-hr period by undergraduate students in analytical chemistry laboratory class settings and produced results within the allowable range of 90.0-110.0% as listed in the United States Pharmacopeia. Differences in sensitivity, precision, sample size, time, and reagent use between the three methods were observed.