Date of Award
Fall 12-16-2021
Degree Type
Thesis
Degree Name
Master of Science in Integrative Biology (MSIB)
Department
Biology
Committee Chair/First Advisor
Dr. Martin Hudson
Major Professor
Dr. Christopher Cornelison
Second Committee Member
Dr. Melanie Griffin
Third Committee Member
Dr. Scott Nowak
Abstract
The rapid rise of drug-resistant pathogens is a global health concern. Known pathogens are acquiring resistance to many commonly used drugs, while new drug-resistant pathogens are emerging. These resistant pathogens are responsible for many healthcare-associated infections (HAI) [1, 2]. Candida auris is among these emerging drug-resistant pathogens, first described in 2009. The CDC labels C. auris at the highest level of global public health threat [3,4]. Effective methods of decolonization and control of the organisms have yet to be established, as it is resistant to many agents used for microbial control. Recent research has found that C. auris has the capacity to form biofilms on healthcare surfaces and human skin [1,2]. This research aims to evaluate the role of biofilm formation of C. auris in its heightened antimicrobial resistance and high transmissibility, causing outbreaks in clinical settings. This study will explore the biofilm formation of C. auris, focusing on structural characteristics, nutrient utilization, and antimicrobial resistance.