Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities
Department
Chemistry and Biochemistry
Document Type
Article
Publication Date
5-1-2016
Abstract
We have developed a multimodal ion source design that can be configured on the fly for various analysis modes, designed for more efficient and reproducible sampling at the mass spectrometer atmospheric pressure (AP) interface in a number of different applications. This vacuum-assisted plasma ionization (VaPI) source features interchangeable transmission mode and laser ablation sampling geometries. Operating in both AC and DC power regimes with similar results, the ion source was optimized for parameters including helium flow rate and gas temperature using transmission mode to analyze volatile standards and drug tablets. Using laser ablation, matrix effects were studied, and the source was used to monitor the products of model prebiotic synthetic reactions.
Journal Title
Journal of the American Society for Mass Spectrometry
Journal ISSN
1879-1123
Volume
27
Issue
5
First Page
897
Last Page
907
Digital Object Identifier (DOI)
10.1007/s13361-016-1354-8