Title

Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities

Department

Chemistry & Biochemistry

Document Type

Article

Publication Date

5-1-2016

Abstract

We have developed a multimodal ion source design that can be configured on the fly for various analysis modes, designed for more efficient and reproducible sampling at the mass spectrometer atmospheric pressure (AP) interface in a number of different applications. This vacuum-assisted plasma ionization (VaPI) source features interchangeable transmission mode and laser ablation sampling geometries. Operating in both AC and DC power regimes with similar results, the ion source was optimized for parameters including helium flow rate and gas temperature using transmission mode to analyze volatile standards and drug tablets. Using laser ablation, matrix effects were studied, and the source was used to monitor the products of model prebiotic synthetic reactions.

Journal

Journal of the American Society for Mass Spectrometry

Journal ISSN

1879-1123

Volume

27

Issue

5

First Page

897

Last Page

907

Digital Object Identifier (DOI)

10.1007/s13361-016-1354-8