Department

Molecular & Cellular Biology

Document Type

Article

Publication Date

1-18-2016

Abstract

MicroRNAs (miRNAs) are short sequences of noncoding single-stranded RNAs that exhibit inhibitory effects on complementary target mRNAs. Recently, it has been discovered that certain viruses express their own miRNAs, while other viruses activate the transcription of cellular miRNAs for their own benefit. This review summarizes the viral and/or cellular miRNAs that are transcribed during infection, with a focus on the biomarker and therapeutic potential of miRNAs (or their antagomirs). Several human viruses of clinical importance are discussed, namely, herpesviruses, polyomaviruses, hepatitis B virus, hepatitis C virus, human papillomavirus, and human immunodeficiency virus.

Journal

Biomarker Insights

Journal ISSN

1177-2719

Issue

4

First Page

25

Last Page

52

Digital Object Identifier (DOI)

10.4137/BMI.S29512

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