Title

Effects of Cytidine Analogs on Methylation of DNA and Retrovirus Induction

Department

Molecular & Cellular Biology

Document Type

Article

Publication Date

5-1988

Abstract

Several cytidine analogs with known mutagenic capability were tested for their effects on DNA methylation and on induction of endogenous murine retrovirus. For each of the compounds tested it was found that DNA methylation was inhibited at the same concentrations that were required to induce virus expression. With each compound it was observed that increased dose levels produced an increase in the ability to inhibit methylation and an increase in the ability to induce virus.

Journal

Mutation Research Letters

Volume

208

Issue

1

First Page

21

Last Page

25

Digital Object Identifier (DOI)

10.1016/0165-7992(88)90015-2