Effects of Cytidine Analogs on Methylation of DNA and Retrovirus Induction
Department
Molecular and Cellular Biology
Document Type
Article
Publication Date
5-1988
Abstract
Several cytidine analogs with known mutagenic capability were tested for their effects on DNA methylation and on induction of endogenous murine retrovirus. For each of the compounds tested it was found that DNA methylation was inhibited at the same concentrations that were required to induce virus expression. With each compound it was observed that increased dose levels produced an increase in the ability to inhibit methylation and an increase in the ability to induce virus.
Journal Title
Mutation Research Letters
Volume
208
Issue
1
First Page
21
Last Page
25
Digital Object Identifier (DOI)
10.1016/0165-7992(88)90015-2
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