Title

Mild Generation of o-Quinone Methides. Synthesis of (-)-Hexahydrocannabinol and Dihydrocannabidiol

Document Type

Article

Publication Date

2000

Abstract

(-)-Hexahydrocannabinol 7 was synthesized enantioselectively under mild conditions through the ortho quinone methide mediated cyclization of the adduct of R-(+)-citronellal and the bisethoxyethyl ether of olivetol. The conditions enabled the ene product, 1, 2-dihydrocannabidiol6, to be isolated as well.